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. 2020 May 19;8:384. doi: 10.3389/fbioe.2020.00384

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Copyright © 2020 Boffito, Torchio, Tonda-Turo, Laurano, Gisbert-Garzarán, Berkmann, Cassino, Manzano, Duda, Vallet-Regí, Schmidt-Bleek and Ciardelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Release of Ru dye from MSN-CS-SIP-Ru-containing hydrogels (NHP407_MSN-CS-SIP-Ru in black, SHP407_MSN-CS-SIP-Ru in gray) in aqueous media at pH 5 and pH 7.4. (A) Ru release from SHP407_MSN-CS-SIP-Ru hydrogels incubated in acetate buffer at pH 5 (continuous line) or in phosphate buffered saline (pH 7.4) (dashed line). (B) Trend of Ru release in pH 5 aqueous environment from NHP407_MSN-CS-SIP-Ru (black continuous line) and SHP407_MSN-CS-SIP-Ru hydrogels (gray continuous line) within the first 4 days of observation. (C) Ru release in PBS (pH 7.4) from NHP407_MSN-CS-SIP-Ru (black dashed line) and SHP407_MSN-CS-SIP-Ru hydrogels (gray dashed line) within the first 4 days of observation.