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. 2020 May 19;14:135. doi: 10.3389/fncel.2020.00135

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Copyright © 2020 Suleimanova, Talanov, Gafurov, Gafarov, Koroleva, Virenque, Noe, Mikhailov, Nistri and Giniatullin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The model of meningeal afferents with different rates of ATP hydrolysis. (A) Schematic presentation of the multi-compartment model of neuro-immune synapse with ATP release from mast cells and acting to several neighboring nerve compartments. (Ba) ATP concentration via diffusion to each (1, 2, 3, 4) nerve compartment without hydrolysis. (Bb) ATP concentration at each compartment with partial hydrolysis (degradation coefficient 0.01). (Ca,b,c) Spiking activity with no ATP hydrolysis (Model 1), with low ATP hydrolysis (Model 2) and high rate of hydrolysis (degradation coefficient 0.8; Model 3), respectively.