TABLE 2.
Top 20 nodes of DEGs in PPI network conducted based on 514 DEGs between CRA tissues and normal tissues.
| Gene | Degree | Gene | Betweenness | Gene | Closeness |
| PHLPP2 | 44 | PHLPP2 | 19635.186 | MYC | 0.03199684 |
| MYC | 39 | MYC | 12719.717 | IGF1 | 0.031952664 |
| IGF1 | 37 | CD44 | 9873.984 | PHLPP2 | 0.031896044 |
| CD44 | 33 | IGF1 | 9854.683 | CXCL12 | 0.03188035 |
| GNB4 | 33 | CSF1R | 7981.7646 | CD44 | 0.031858407 |
| CXCL12 | 30 | DCN | 7626.397 | GNB4 | 0.031858407 |
| SST | 29 | GNB4 | 6612.885 | MET | 0.031808365 |
| CSF1R | 26 | PRKCB | 4880.521 | CSF1R | 0.031805243 |
| ADCY9 | 26 | APOE | 4200.9272 | CCL5 | 0.031789638 |
| GNG2 | 26 | CCND1 | 3927.6084 | APOE | 0.031739812 |
| GNG7 | 25 | MET | 3911.5237 | SST | 0.031739812 |
| CCR2 | 24 | CXCL12 | 3789.8855 | GCG | 0.031714957 |
| NPY | 24 | GCG | 3778.8518 | DCN | 0.031702545 |
| CCL5 | 24 | PRKAR2B | 3672.393 | CCR2 | 0.03168704 |
| GCG | 23 | ITGA2 | 3342.6714 | ADCY9 | 0.031683944 |
| DCN | 21 | CCL5 | 2937.6538 | ITGA2 | 0.031656083 |
| CCL19 | 21 | ADCY9 | 2931.6262 | GNG2 | 0.031646807 |
| PF4 | 21 | CACNA1C | 2881.468 | VIP | 0.031643715 |
| ITGA2 | 20 | KLRD1 | 2849.4792 | CCND1 | 0.031631358 |
| APOE | 20 | LGR5 | 2745.487 | KLF4 | 0.03161901 |
Degree, results of degree centrality algorithm; betweenness, results of betweenness centrality algorithm; closeness, results of Closeness centrality algorithm; DEG, differentially expressed genes; PPI, protein–protein interaction.