Table 4.

Metabolites identified in obese BC compared with non-obese BC patients.

Category	Compound	Log2FC	p-value
Metabolite involved in epigenetic	Ornithine	2.42	<0.0001
	7-Methyladenine	2.40	<0.0001
	2-Oxoarginine	1.74	<0.0001
Metabolite involved in citric acid cycle	L-Carnitine	1.83	<0.0001
	Glycerol 3-phosphate	2.38	<0.0001
	L-2-Hydroxyglutaric acid	0.71	0.0004
	Pentanoyl-CoA	−1.95	0.0001
Amino acid metabolism	Ornithine	2.42	<0.0001
	2-Oxoarginine	1.74	<0.0001
	Serotonin	0.73	0.0003
	Histamine	0.76	0.003
	Tryptophan	0.42	0.024
	L-Homoserine	0.44	0.038
	D-Leucine	2.34	<0.0001
	3-Hydroxyphenylacetic acid	−4.97	<0.0001
	Carbamoyl phosphate	−1.36	0.0001
	FAD	−2.28	0.0002
	Epinephrine	−0.33	0.0003
	Creatinine	−0.40	0.01
Cholesterol and fatty acid metabolites	25-Hydroxycholesterol	2.31	<0.0001
	Cholestenone	−7.85	<0.0001
	TG[16:0/14:1(9Z)/18:4(6Z,9Z,12Z,15Z)]	−1.52	0.0006
	Alpha-Linolenic acid	−0.77	0.002
	Hexanoyl-CoA	−1.71	0.0004
Neurotransmitters	Epinephrine	−0.33	0.0003
	Serotonin	0.73	0.0003
	SM[d19:1/24:1(15Z)]	6.55	0.0008
	Histamine	0.76	0.003
	Acetylcholine	0.55	0.007

FC, fold change.