Figure 7.

Murine nociception induced by heat stimuli applied to the paw. (A) BOLD patterns along the spinothalamic (LST) and spinoreticular tract (SST) depict well-known nociceptive routes in the mouse with high spatial accuracy, including thalamic nuclei (TN), primary (S1) and secondary (S2) somatosensory cortex, the barrel field (S1_BF), and insular (IC) and ACC. (B) Involvement of the habenula nociceptive pathway (HNP) has also been observed, including amygdala (AM), hippocampal areas (HC), entopenduncular nucleus (EP), and the small nuclei of the lateral habenula (L_Hb). These highly precise patterns represented the tip of the iceberg of underlying BOLD effects, likely induced by MABP surges and vasodilative projections from subcortical arousal nuclei. Adapted from Reimann et al. (2016), http://creativecommons.org/licenses/by/4.0.