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. 2020 May 19;8:463. doi: 10.3389/fbioe.2020.00463

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Copyright © 2020 Zheng, Tian, Gao, Yu, Xia, Feng, Dong, Wu and Sui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Surface topography influences cell osteogenic differentiation. (A) The relative mRNA levels of Runx2, Col1a1 and Ocn in cell cultured on different materials for 3 and 7 days. (B) Western blot analysis of Runx2, Col1a1, and Ocn in cell cultured on different materials for 3 and 7 days. (C) Immunofluorescence staining showing surface topography dependent diverse expression of Runx2 in cell cultured on different materials for 3 days. (red, F-actin; blue, DAPI; green, Runx2). (D) The relative mRNA and protein levels of integrin α2 in cell cultured on different materials for 3 and 7 days. Statistical significance was determined by one-way ANOVA. Error bars represent SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.005.