Table 5.

Combinations of metals/related linker and their role in various biomedical applications.

Sr. no.	Metal ion	Organic linker	MOFs	Potential applications	References
1	Zn	2-Methylimidazole	ZIF-8	Drug delivery (doxorubicin drug)	Vasconcelos et al., 2012
2	Zr	2-Aminoterephthalic acid	UiO-66	Drug delivery (drug caffeine)	Nagata et al., 2015
3	Zn	1,1′,4′,1″,4″,1-Quaterphenyl-3,5,3,5-tetracarboxylic acid 1,3,5-benzenetrisbenzoate	(NH2(CH3)2[Zn3(L)2 · 3.5DMF])	Drug delivery	Li Q. L., et al., 2015
4	Cu	[1,1′;3′,1″] terphenyl-4,5′,4″-tricarboxylic acid) and pyrazine	[Cu3L2(pyrazine) (H2O)]	Drug delivery of ibuprofen	Wei et al., 2016
5	Cu	5-NH2-m-benzenedicarboxylate	MOP-15	Drug delivery	Wang et al., 2011
6	Fe3+	2-Amino terephthalic acid	Fe-MIL-53-NH2-FA-5-FAM/5-FU	MRI and optical bioimaging	Gao et al., 2017
7	Gd3+	4-Dimethylaminopyridine	Gd-DTPA-FITC-CS11	Bioimaging	Wang et al., 2016
8	Zn	2-Methylimidazole	Fe3O4@PAA/AuNCs/ZIF-8 nanoparticles	MRI and CT bioimaging	Bian et al., 2015
9	Gd3+	Ru[4,4′-(COOH)2bipyridyl(bpy)]3	Gd-Ru MOFs	MRI and optical bioimaging	Huang et al., 2016
10	Fe3+	Fumarate	Au@MIL-88(A)	CT bioimaging	Shang et al., 2017
11	Cu	H3btc	Cu-BTC(MOF-199)	Antibacterial application	Rodríguez et al., 2014
12	Co	H8 tdm: tetrakis [(3,5-dicarboxyphenyl)-oxamethyl] methane	Co-TDM	Highly effective bactericidal activities application	Zhuang et al., 2012
13	Ag	HO-H2ipa = 5-hydroxyisophthalic acid and H2pydc = pyridine-3, 5-dicarboxylic acid	Ag2(O-IPA)(H2O)·(H3O) and Ag5(PYDC)2(OH)	Antibacterial application	Indumathy et al., 2007
14	Zn	—	Bio-MOF-100	Drug loading and release for immobilization of biomolecules	An et al., 2012
15	Mg	H4gal	Mg(H4gal)	Antioxidant carrier application	Hidalgo et al., 2017
16	Zn	AzA: azelaic acid	BioMIL-5	Antibacterial application	Tamames-Tabar et al., 2015