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. 2020 May 19;11:979. doi: 10.3389/fmicb.2020.00979

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Copyright © 2020 Yasunaga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tax is transiently expressed in an ATL cell line, MT-1. (A) Structure of the provirus and the tax and HBZ genes. (B) Time-lapse imaging of Tax expression in MT-1 cells. Destabilized EGFP protein (d2EGFP) expressed under the control of Tax-responsive elements is used to visualize Tax expression. The image was modified from the one obtained in the author’s previous work (Mahgoub et al., 2018). (C) Tax is transiently expressed, and HBZ expression is oppositely regulated (Mahgoub et al., 2018). Prolonged induction of anti-apoptotic genes is observed even after Tax is diminished, and this may be important for maintenance of the MT-1 cell population.