Figure 2.

The pooled MD of primary outcomes. The red square indicates the estimated MD for each RCT. The size of red square indicates the estimated weight of each RCT, and the extending lines indicate the estimated 95% CI of MD for each RCT. The black diamond indicates the estimated MD (95% CI) for all patients together. (A) Mean monthly headache days, baseline to week 12. (B) Mean monthly migraine days, baseline to week 12. Weights are from random-effects analysis. CI, confidence interval; RCT, randomized controlled trial; MD, mean difference.