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. 2020 May 19;11:352. doi: 10.3389/fneur.2020.00352

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Copyright © 2020 Yang, Peng, Wang, Huang, Ran, Chen and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receiver operating characteristic analyses showing the combined diagnostic utility of the panel including APOB, APOC1, LBP, VCAM1, FBLN1, and FCN2 in CAD. By leave-one-out (LOO) cross-validation, ELISA-based ROC analyses of combined quantitation of APOB, APOC1, LBP, VCAM1, FBLN1, and FCN2 showing promising for the detection of increased CAD risk in stroke subjects (PANEL = APOB + APOC1 + LBP + VCAM1 + FBLN1 + FCN2). The AUC of panel (A) was 1, and the panel exhibited a higher sensitivity (100%) and specificity (100%) than the six proteins individually (B).