Fig. 1.

Reduced plasma BMP9 and pBMP10 levels and increased sEng levels in cirrhosis are associated with decompensation. (A,D,G) Plasma samples from controls or patients with either pre-cirrhotic liver fibrosis or with cirrhosis were assayed by ELISA for (A) BMP9, (D) pBMP10 or (G) sEng. Error bars show median and interquartile range. (B,E,H) Spearman correlation of: (B) BMP9 (n = 69, P<0.0001), (E) pBMP10 (n = 64, P<0.0001) or (H) sEng (n = 58, P<0.0001) levels with MELD-Na score of cirrhosis severity. (C,F,I) Patients were stratified for compensated and decompensated liver disease and plasma levels of (C) BMP9, (F) pBMP10 and (I) sEng compared between groups. Kruskal Wallis test: *P<0.05, ***P<0.001, ****P<0.0001, Mann Whitney Test #P<0.05.