Table 3.
Patient characteristics |
PDX characteristic | CD24 status |
|||||
---|---|---|---|---|---|---|---|
PDX | Age | Histology | FIGO | PFS (months) | Disease Latency (weeks) | Patient (SI) | PDX (SI) |
1 | 52 | HGSOC | IV | 9 | 11 | 4 | 9 |
2 | 38 | HGSOC | IIIC | 40 | 19 | 9 | 9 |
3 | 75 | HGSOC | IIIC | 9 | 61 | 6 | 6 |
4 | 42 | HGSOC | IIIC | 13 | 16 | 9 | 4 |
5 | 64 | HGSOC | IIA | 2 | 13 | 6 | 6 |
6 | 78 | Clear cell | IA | 19 | 54 | 4 | 4 |
7 | 60 | Anaplastic | IIIC | 1 | 9 | 0 | 2 |
Clinical characteristics: Patient age at primary treatment, histological subtype of epithelial ovarian carcinoma, FIGO 2014 stage, progression-free survival (PFS), engraftment time in immunodeficient mice and CD24 expression status of the original patient material and the corresponding PDX sample indicated as immunohistochemical staining index (SI). SI = CD24 staining intensity (0–3) x positive stained area (0–3); 0 = no expression, 9 = strong expression. PFS was defined as time in months from the first day of primary treatment to disease recurrence.