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. 2020 Apr 21;22(1):483–493. doi: 10.3892/mmr.2020.11085

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Increased expression of miR-93 attenuates cardiac dysfunction after MI. (A) miRNAs were isolated from sham-operated and infarcted hearts at 1, 3 and 7 days after MI. RT-qPCR analysis revealed a downregulation of miR-93 expression in the myocardium after MI. n=4-5 mice per group. (B) Representative images of heart sections at 7 days after transfection with lentiviral vectors (magnification, ×200). RT-qPCR revealed the expression level of miR-93 in the myocardium after transfection. n=4-5 mice per group. (C) Representative images of M-mode echocardiography at baseline and 21 days after MI. Echocardiography parameters were measured at baseline and at 3, 14 and 21 days after MI. Increased expression of miR-93 reversed MI-induced decreases in (D) EF% and (E) FS%. n=5-7 mice per group. Data are presented as the mean ± SEM. *P<0.05 vs. the indicated group. scr, scrambled; miR/miRNA, microRNA; MI, myocardial infarction; LV, lentivirus; EF, ejection fraction; FS, fraction shortening; RT-qPCR, reverse transcription-quantitative PCR.