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. 2020 Apr 21;22(1):483–493. doi: 10.3892/mmr.2020.11085

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Increased expression of miR-93 promotes angiogenesis and attenuates collagen deposition after MI. (A) Representative immunohistochemical images of CD31 in the heart sections (magnification, ×200). Quantitative analyses revealed the enhancement of microvascular density in miR-93-transfected hearts after MI. n=3 mice per group. (B) Representative images of collagen deposition in the heart sections (magnification, ×12.5). Quantitative analyses demonstrated the attenuation of cardiac fibrosis by transfected with lentivirus expressing miR-93 after MI. n=3-5 mice per group. (C) Reverse transcription-quantitative PCR analysis demonstrated the downregulation of MMP-2 mRNA expression in miR-93-transfected hearts after MI. n=4-5 mice per group. Data are presented as the mean ± SEM. *P<0.05 vs. the indicated group. MI, myocardial infarction; scr, scrambled; miR, microRNA; MMP-2, matrix metalloproteinase 2; ns, not significant.