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Effects of Dex on apoptosis and pyroptosis during sepsis. Changes in the protein expression levels of (A) cleaved caspase 3 and (B) caspase 9. (C) Bax/Bcl-2 ratio. (D) Changes in the protein expression of GSDMD. Sepsis was achieved by CLP. Data are presented as the mean ± SEM. n=6 per group. *P<0.05 and **P<0.01. Dex, dexmedetomidine; GSDMD, gasdermin D; CLP, cecal ligation and puncture; YOH, yohimbine hydrochloride; ns, normal control; C, control; ns, not significant.
