Table I.

Study characteristics.

Study	Type	Primary findings	(Refs.)
Song et al, 2019	Research	NMN promotes osteogenesis via SIRT1	(16)
Zainabadi, 2019	Review	NMN improve osteogenesis	(45)
Liang et al, 2019	Research	NMN alleviates aluminum-induced bone loss by inhibiting the thioredoxin-interacting protein-NLRP3 inflammasome	(42)
Hassan et al, 2018	Research	Nicotinamide phosphoribosyltransferase expression in osteoblasts controls osteoclast recruitment in alveolar bone remodeling	(46)
Mills et al, 2016	Research	Long-term NMN administration significantly improves bone density	(47)
Baek et al, 2017	Research	Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro	(48)
Abed et al, 2014	Research	Low SIRT1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity	(49)

NMN, nicotinamide mononucleotide; SIRT1, sirtuin 1; NLRP3, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3.