Table II.
Effects of IPostC with the miR-499 mimic, inhibitor and negative control AAV vectors on the levels of TLR2, PKC, IL-1β and IL-6 in the serum following myocardial I/R.
| Groups | TLR2, pg/ml | PKC, pg/ml | IL-1β, pg/ml | IL-6, pg/ml |
|---|---|---|---|---|
| Sham | 16.7±2.8 | 320.4±17.2 | 35.5±4.2 | 68.4±7.3 |
| I/R | 28.4±3.9a | 1036.5±30.1a | 60.6±5.8a | 156.9±10.5a |
| IPostC | 23.1±3.3b | 720.1±24.9b | 51.9±5.0b | 108.7±8.9b |
| IPostC + NC | 22.4±3.2 | 717.2±26.0 | 52.1±3.0 | 107.9±8.0 |
| IPostC + inhibitors | 32.8±5.5c | 987.7±28.7c | 68.5±3.1c | 178.5±7.8c |
| IPostC + mimics | 13.6±2.9c | 505.2±19.7c | 37.0±1.8c | 77.1±4.9c |
Data are presented as the mean ± SD.
a
P<0.05 vs. sham group.
b
P<0.05 vs. I/R group.
c
P<0.05 vs. IPostC group. n=8 per group. IL, interleukin; TLR, Toll-like receptor; PKC, protein kinase C; NC, negative control; IPostC, ischemic postconditioning; IR, ischemia/reperfusion; miR, microRNA.