Figure 9.

Lesion size and lateral ventricle size. PhenT treatment (2.5 mg/kg, BID × 5 days after CCI) reduced lesion volume (A) and lateral ventricle (LV) swelling (B) evaluated 2 wk after CCI. Lesion volume was quantified using IMAGE‐PRO PLUS 6 software (Media Cybernetics).41 (A) Significant reduction of lesion size was found in the PhenT group. *P < .05, ***P < .001, vs vehicle‐treated and CCI‐only groups. (B) Significant differences in LV size ratio between ipsilateral and contralateral sides were also found between PhenT‐ and saline‐treated groups (*P < .05). Analysis by one‐way repeated measure ANOVA followed by Holm‐Sidak method. Data are mean ± SEM; n = 4 (SHAM, CCI, CCI + Saline), n = 7 (CCI + PhenT)