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. 2020 May 19;7:256. doi: 10.3389/fvets.2020.00256

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Copyright © 2020 Wallace, Mather, Kara, Naicker, Mokoena, Pretorius, Nefefe, Thema and Babiuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RVFV neutralizing antibody titres in calves. (A) Mock-vaccinated animals had no detectable virus neutralizing antibody levels at any days' post-inoculation (dpi) and are therefore not represented on the graph. Highest levels of neutralizing antibody titres were observed in all animals by 9 dpc. Animal D2-5 is not shown on the graph as neutralizing antibodies were not detected at 3 day's post-challenge (dpc), however, the animal died of acute RVF at 5 dpc. (B) Three calves inoculated with the LSD-RVF.mf vaccine sero-converted post-vaccination. A significant increase in titres were observed following challenge in all animals by 9 dpc (testing was performed up to a limit of 1:320 serum dilution, thus all final titres are higher).