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. 2020 May 19;11:931. doi: 10.3389/fimmu.2020.00931

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Copyright © 2020 van Daalen, Reijneveld and Bovenschen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suggested mechanism resulting in extracellular granzyme A release. Granzyme A can be release as a result of (1) constitutive granzyme A secretion after degranulation, (2) leakage of granzyme A from the immunological synapse, (3) degranulation after engagement of integrin with the ECM, (4) induction of degranulation by locally released chemokines (5) induction of degranulation by bacteria or LPS (8).