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. 2020 Apr 8;14(6):459–479. doi: 10.2217/bmm-2019-0333

Table 2. . Comparison of typical findings for common cerebrospinal fluid laboratory tests by etiology of meningitis.

Meningitis Etiology Total Protein CSF/blood glucose ratio Total WBC Predominant WBC type
Bacterial +++ +++ +++ Neutrophils
Aseptic (Viral) ± ± ± Lymphocytes
Tuberculosis ++ +++ ++ Lymphocytes
Cryptococcal ++ ++ ± Lymphocytes
Coccidioidal ++ + ± Lymphocytes
Blastomyces ++ ++ ± Lymphocytes
Histoplasma ++ ++ ± Lymphocytes
Aspergillus ++ + ± Lymphocytes

May be neutrophil predominant early in the disease course.

Eosinophilic predominance occurs less commonly but when seen is highly suggestive.

The number of + signs indicate proportional gradient of increase (total protein or total WBC) or decease (ratio of CSF/blood glucose) of the lab test. To indicate proportionally minimal or no increase/decrease, ± is used. WBC differential indicates the dominant cell type present although other cells generally are present as well.

CSF: Cerebrospinal fluid; WBC: White blood cell.