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Superimposition of the crystal structure of the MOR (PDB ID: 5C1M) with co-crystallized BU72 (grey), and the recently available cryo-EM structure (PDB ID: 6DDF) with bound DAMGO (blue) in a transmembrane (A) and extracellular view (B). The close-up view on DAMGO (blue surface) in the binding site (C) unveils a sterical clash (circle) of the peptide with the N-terminus resolved in the active crystal structure.
