Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 28;25(9):2050. doi: 10.3390/molecules25092050

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme 2 — Reagents and conditions: (i) 6, ⁿBuLi, anisole, ether, −70 °C; (ii) (Boc)₂O, CH₂Cl₂, 85% over two steps; (iii) 1M HCl, MeOH, 30 °C, 96%; (iv) 1,3-Dichloro-1,1-3,3-tetraisopropyldisiloxane, pyridine, 81%; (v) O-Phenyl chlorothionoformate, MeCN, 90%; (vi) 1,1′-Azobis(cyclohexane-1-carbonitrile), toluene reflux, 91%; (vii) Pd(OH)₂, H₂, EtOH, conc. NH₄OH, 90% and (viii) conc. HCl, MeOH, reflux, 83%.