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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Distance of the deep (red), central (green) and outer (orange) H-bond interactions across 100 ns MD simulation of derivatives 1–18. The plots are ordered per INDZ-IMID 1-IMID 2 triplet. Dashed lines represent the mean value of the H-bond distance.