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. 2020 May 6;25(9):2170. doi: 10.3390/molecules25092170

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hematoxylin-eosin staining of U87-MG tumour: (A) tumour bulk in the right striatum of a mouse brain (×2, scale bar: 1000 µm); (B) tumour periphery presents area of high density of cell nuclei; (C) tumour centre presents area of lower cell density accompanied by oedema. (×40, BAT: brain adjacent to tumour; T: tumour, E: oedema. Scale bar: 100 µm. (D) Representatives coronal PET/MR images of U87-MG tumour-bearing mouse after i.v. administration of (S)-(−)-[¹⁸F]fluspidine. The upper panel exhibits the distribution of (S)-(−)-[¹⁸F]fluspidine at early times p.i. (averaged time frames from 2 to 9 min), and the lower panel exhibits the distribution of (S)-(−)-[¹⁸F]fluspidine at later times (averaged time frames from 45 to 60 min).