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. 2020 May 8;25(9):2208. doi: 10.3390/molecules25092208

Figure 1.

Figure 1

Inositol pyrophosphate biosynthetic pathway. This diagram illustrates the metabolic routes of inositol poly- and pyro-phosphate synthesis in mammalian cells. Sequential phosphorylation of IP3 by IPMK and other IP kinases (e.g., IP3-kinases, IP5-2K) yields IP6. Pyrophosphorylation of IP6 by IP6Ks and PPIP5Ks finally leads to the production of PP-IPs (e.g., 5-IP7). PP-IPs are highlighted in blue. ITPK, inositol trisphosphate 3-kinase; IPMK, inositol polyphosphate multi-kinase; INPP5, inositol polyphosphate 5-phosphatase; IP5-2K, inositol pentakisphosphate 2-kinase.