Table 2.
Bioavailability levels for GCE components according to their physicochemical properties (A) most potent, (B) medium, (C) less potent to penetrate stratum corneum.
| Bioavailability Level | Polyphenol | Compliance with the Bioavailability Rules | ||||
|---|---|---|---|---|---|---|
| Lipinski [33] |
Ghose [34] |
Veber [35] |
Egan [36] |
Muegge [37] |
||
| A | catechin | yes | yes | yes | yes | yes |
| A | epicatechin | yes | yes | yes | yes | yes |
| A | E-resveratrol | yes | yes | yes | yes | yes |
| A | E-piceatannol | yes | yes | yes | yes | yes |
| A | ampelopsin A | yes | yes | yes | yes | no |
| B | E-ε-viniferin | yes | no | yes | yes | no |
| C | hopeaphenol | no | no | no | no | no |
| C | isohopeaphenol | no | no | no | no | no |
| C | E-miyabenol C | no | no | no | no | no |
| C | E-vitisin B | no | no | no | no | no |