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Imaging of 68Ga-labeled IRDdye800CW-FSC-(PEG5-Tz)2 in mice receiving alendronate alone (left row) or alendronate-TCO (right), PET/CT images: transverse slices (top) and sagittal slices (middle), yellow arrows indicate uptake in joints and spine, white arrow indicates the bladder. Bottom image: Optical image of excised bones of the lower limbs. Both PET and OI indicate higher accumulation in bone of alendronate-TCO pre-treated mice as compared to controls.
