Table 1.

Distribution coefficient (logD) and protein binding of ⁶⁸Ga-labeled FSC-based Tz-bearing hybrid imaging agents.

68Ga-Labeled Conjugate	Distribution Coefficient	Protein Binding (%)
	logD (pH 7.4)	1 h	2 h	4 h
SulfoCy5-MAFC-PEG5-Tz	−2.85 ± 0.08	37.0 ± 0.3	37.4 ± 2.3	37.6 ± 1.2
SulfoCy7-MAFC-PEG5-Tz	−1.92 ± 0.05	36.9 ± 0.8	40.4 ± 1.5	41.6 ± 2.7
IRDye800CW-MAFC-PEG5-Tz	−2.40 ± 0.05	65.7 ± 1.3	67.3 ± 1.4	67.7 ± 0.2
SulfoCy5-FSC-(PEG5-Tz)2	−2.29 ± 0.10	35.7 ± 0.7	39.1 ± 0.4	40.8 ± 0.6
IRDye800CW-FSC-(PEG5-Tz)2	−2.46 ± 0.09	47.3 ± 0.2	50.3 ± 0.3	54.9 ± 1.1

Data are presented as mean ± SD (n = 3).