Table 1.

In vitro antiplasmodial activities of bisquinoline and related compounds.

Compound	Activity (IC50; nM)			Cytotoxicity	Structure
	D6	Dd2	7G8	(LC50; nM) Mouse Spleen Lymphocytes
CQ	6.9	102	106	12,400
PPQ	0.7	1.5
1	1.3	4.1	7.4
2 [46]	2.4	3.7	1.5	1100
3	1.5	5.0		1600
4 (DM1157) [46,47]	0.2	2.2	1.8	6500
5 [45]	0.4	0.7	0.1
6	0.15	0.36	0.33	190
7	4.9	9.8	25
8	0.68	2.1	0.63
9	0.68	2.1	0.41
10	15	89	106
11	3.0	<2.5	<2.5
12	4.5	<2.5	<2.5
13	33	56	100