Table 2.

HDAC inhibitory activities of largazole-based synthetic analogues 3 to 6 (IC₅₀ nM).

HDAC	Compound
	3	4	5	6
1	2.20	21.0	1.0	40.0
2	4.42	28.0	1.9	90.0
3	2.31	27.0	1.5	43.0
5				>10,000
6	35.16	13,000	0.24	2800
8	101.8			9600
10				3.6