Table 3:
Summary of top 25 potentially novel candidate protein complexes. For each candidate predicted complex, we list the complex members, complex score, top GO annotations from g:Profiler and their p-value, STRING score (experimental only) and minimum Pearson correlation coefficient.
| Predicted complex | Complex score | Top GO annotation (p-value) | STRING score | Pearson corr. coeff. (min) |
|---|---|---|---|---|
| ACTR1A, DCTN4, ACTR10 | 0.93 | Dynactin complex (3.1E-5) | 0.879 | - |
| DLAT, DLD, PDHA1 | 0.92 | Pyruvate dehydrogenase complex (3.7E-9) | 0.839 | −0.199 |
| DLAT, PDHA1, PDHB | 0.92 | Pyruvate dehydrogenase complex (3.7E-9) | 0.895 | - |
| ACTR1B, ACTR10, DCTN4 | 0.92 | Dynactin complex (3.1E-5) | 0.862 | - |
| ACTR1B, DCTN1, DCTN2, DCTN4 | 0.91 | Dynactin complex (1.1E-8) | 0.855 | - |
| ARCN1, COPA, COPB1, COPB2, COPG1 | 0.90 | COPI vesicle coat (2.1E-14) | 0.943 | 0.736 |
| NUP62, NUP88, NU214 | 0.90 | Nuclear pore (1.3E-5) | 0.867 | - |
| NSMCE1, NSMCE2, SMC5, SMC6 | 0.90 | Smc5-Smc6 complex (2.4E-12) | 0.956 | - |
| NSMCE1, NDNL2, SMC5, SMC6 | 0.89 | Smc5-Smc6 complex (2.4E-12) | 0.957 | - |
| POLR3A, POLR3C, POLR3F, CRCP | 0.89 | RNA polymerase III complex (2.1E-10) | 0.856 | - |
| ACTR1A, DCTN1, DCTN2, DCTN4, CAPZA2 | 0.88 | Antigen processing and presentation (8.8E-8) | 0.809 | −0.347 |
| POLR3A, POLR3B, POLR3C, POLR3F, POLR3G, POLR3H | 0.88 | RNA polymerase III complex (9.4E-17) | 0.872 | - |
| TMED2, TMED3, TMED10 | 0.88 | COPI-coated vesicle (1.5E-7) | 0.858 | - |
| KPNA3, KPNA4, RANGAP1 | 0.88 | Protein localization to nucleus (9.4E-4) | 0.282 | 0.294 |
| AP2A1, AP2B1, AP2M1 | 0.88 | AP-2 adaptor complex (4.1E-8) | 0.911 | - |
| DCTN2, DCTN4, DCTN5 | 0.87 | Dynactin complex (3.1E-5) | 0.936 | - |
| DCTN4, DCTN5, DCTN6 | 0.87 | Antigen processing and presentation (5.7E-4) | 0.924 | - |
| COPA, COPB1, COPE, COPG1 | 0.87 | COPI vesicle coat (4.9E-11) | 0.943 | 0.857 |
| NDNL2, NSMCE1, NSMCE2, SMC5, SMC6 | 0.86 | Smc5-Smc6 complex (3.5E-16) | 0.964 | - |
| ARCN1, COPA, COPB1, COPB2, COPE, COPG1 | 0.84 | COPI vesicle coat (8.7E-18) | 0.944 | 0.736 |
| SEC23B, SEC24A, SEC24C | 0.80 | 6-phosphofructokinase activity (2.8E-5) | 0.900 | - |
| HYPK, NAA10, NAA16 | 0.80 | NatA complex (3.05E-5) | 0.535 | 0.988 |
| CYC1, UQCRQ, UQCRQ2, UQCRFS1 | 0.79 | Mitochondrial respiratory chain complex III (3.3E-11) | 0.851 | - |
| NHP2, NOP10, RIOK1 | 0.78 | snRNA pseudouridine synthesis (3.9E-5) | 0.222 | - |
| COPB, PC, PFKL, PFKM | 0.78 | 6-phosphofructokinase activity (2.8E-5) | 0.292 | - |