Table 4.

Associations of HLA-DRB1 haplotypes with subcutaneous nodules and radiographic changes.

Haplotype	Subcutaneous nodules Odds ratio (95% CI)	ACR Radiographic Changes Odds ratio (95% CI)
VKA	1.03 (0.81, 1.32)	1.39 (1.08, 1.80)
VRA	1.02 (0.79, 1.31)	0.97 (0.75, 1.26)
LRA	1.16 (0.90, 1.50)	0.96 (0.73, 1.25)
PRA	1.40 (0.72, 2.72)	1.15 (0.58, 2.30)
VRE	1.14 (0.62, 2.10)	1.81 (0.91, 3.64)
DRE	1.24 (0.70, 2.17)	1.67 (0.93, 2.98)
VEA	0.73 (0.19, 2.81)	2.11 (0.50, 8.82)
SKA	1.15 (0.62, 2.14)	1.10 (0.58, 2.10)
PAA	1.01 (0.76, 1.35)	1.29 (0.96, 1.72)
GRQ	0.85 (0.63, 1.16)	0.82 (0.61, 1.12)
SRA	1.02 (0.73, 1.41)	0.71 (0.51, 1.00)
SRE	0.68 (0.32, 1.44)	0.61 (0.30, 1.26)
LEA	0.91 (0.34, 2.44)	0.63 (0.23, 1.72)
SRL	1.22 (0.70, 2.12)	1.12 (0.63, 2.02)
SKR	0.90 (0.66, 1.22)	0.88 (0.64, 1.20)
SEA	0.84 (0.60, 1.16)	0.76 (0.55, 1.05)
Other genetic parameters
Valine at position 11	1.06 (0.84, 1.35)	1.31 (1.04, 1.67)
Shared epitope positive	1.25 (0.96, 1.63)	1.23 (0.95, 1.60)

Values OR (95% CI) adjusting for age, sex, race, smoking status, and disease duration.