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. 2020 May 25;15:9. doi: 10.1186/s13008-020-00065-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Resumption of Xenopus oocyte meiosis. G2-arrested oocytes contain pre-MPF, i.e. inactive Cdk1-Cyclin B complexes in which Cdk1 is inhibited by T14 and Y15 phosphorylation. Progesterone initiates a signalling pathway that leads to T14-Y15 dephosphorylation of Cdk1. MPF promotes the breakdown of the nuclear envelope (GVBD for germinal vesicle breakdown, identified by a white spot at the pole of the brown hemisphere) and formation of the metaphase I spindle. After extrusion of the first polar body, the metaphase II spindle is organized and the oocyte arrests at this stage, until fertilization. Top: two pictures of Xenopus oocytes, G2 arrest (left) and GVBD (right)