Table 2.

Summary of Case Reports of isolated Zic4-Antibodies

Author	Age/Sex	Associated Tumor	Primary syndrome at Diagnosis	Symptoms	Treatment	Treatment response
Current Study	67/F	SCLC	Brainstem, PCD	Opsoclonus-Myoclonus Syndrome, Dysautonomia	Methylprednisolone, Plasmapheresis, IVIG, Lobectomy, Cyclophosphamide	none
Salazar et al. 2018 [9]	70/M	None, sCJD	Brainstem, PCD	Dementia, Ataxia, Myoclonus, Dysautonomia	Methylprednisolone	none
Eye et al. 2018 [10]	94/F	DLBCL, SMM	PCD	Downbeat Nystagmus, alternating Skew Deviation, Gait Ataxia	Chemotherapy, Rituximab	Improvement but persisting symptoms
Aydin et al. 2018 [11]	40/F	Ductal breast cancer	SSN	Pain, Asymmetric Numbness	n/a	Improvement but persisting symptoms
Kerasnoudis et al. 2011 [12]	60/F	Ovarian adenocarcinoma	PCD	Progressive Gait Ataxia, Dysarthria	Methylprednisolone, Ovariectomy, Chemotherapy	Complete clinical remission
Sabater et al. 2008 [8]	n/a	SCLC	PCD	n/a	n/a	n/a
Bataller et al. 2004 [6]	67a/ 8: M, 1: F	8: SCLC 1: no tumor	7: PCD 1: PCD + LE 1: LEMS	Cerebellar Ataxia Cerebellar Ataxia, Cognitive Dysfunction Myasthenia	n/a	n/a

^amedian age