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. 2020 May 25;17:166. doi: 10.1186/s12974-020-01836-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effect of different doses of DHLA on treatment of sickness behavior rats. a Effect of DHLA and Flu on body weight changes. b–e Depression-like behaviors were assessed by forced swimming test (b) and open field test (c–e). The data were expressed as means ± SEM (n = 6). ****P < 0.0001 versus the control group. ^#P < 0.05; ^##P < 0.01; ^###P < 0.001; ^####P < 0.0001 versus the LPS group. The Shapiro-Wilk test results showed that all the data are normally distributed (p > 0.05)