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. 2020 May 25;17:166. doi: 10.1186/s12974-020-01836-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Blockade of ERK abolished the anti-Inflammation effect of DHLA. a Representative Western blot bands in the hippocampal region. b–f Statistical graphs of relative protein expression of Nrf2 (b), HO-1 (c), NLRP3 (d), caspase-1 (e), and IL-1β (f). g ROS expression in the hippocampal. The data were expressed as means ± SEM (n = 6). ****P < 0.0001 versus the control group. ^#P < 0.05; ^####P < 0.0001 versus the LPS group. ^&P < 0.05; ^&&P < 0.01 versus the LPS + DHLA group. The Shapiro-Wilk test results showed that all the data are normally distributed (p > 0.05)