Table 7.

Small-molecule compounds regulating multi-signaling pathways to inhibit CSCs

Name	Target	Mechanism	Type of cancer	Phase	NCT number (starting time)/publication date	Assessment
Z-ajoene	Notch, Wnt, and Hh	Inhibits CSC sphere-forming ability	Glioblastoma multiforme	Preclinical	July, 2014	Without cytotoxic in normal cells [173]
Poziotinib	Wnt, Notch, and Hh	Decreases ovarian CSC sphere formation ability	Epithelial ovarian cancer	Preclinical	May 21, 2020	Diarrhea and rash [174]
6-Shogaol	Notch and autophagy	Inhibits the number of CD44+/CD24− cell subpopulation and decreases sphere-forming ability	Breast cancer	Preclinical	September 10, 2015	Induces low toxicity in normal cells [175]