FIG. 4.

Circulating plasma levels of C-reactive protein (CRP) and metalloendopeptidase (MME) are associated with traumatic brain injury (TBI). (A) Relative protein abundance for CRP levels measured by isobaric tag for relative and absolute quantitation (iTRAQ) for community controls (CC), deployed controls (DC), and mild TBI (mTBI) subject pools (average of two pools each). (B) log2 transformed CRP levels measured by enzyme-linked immunosorbent assay (ELISA) for individual CC, DC, and mTBI individuals. (C) log2 transformed MME levels (in normalized protein eXpression [NPX] units) measured by Proximity Extension Assay (PEA) for individual CC, DC, and mTBI.