Table 2.
Overlapping miRNAs Showing Differences between mTBI and Controls in Plasma and EVs
| |
Plasma mTBI vs. CC |
Plasma mTBI vs. DC |
EV mTBI vs. CC |
EV mTBI vs. DC |
||||
|---|---|---|---|---|---|---|---|---|
| miRNA | Log2 fold change | p value | Log2 fold change | p value | Log2 fold change | p value | Log2 fold change | p value |
| let-7b-5p | – | – | – | – | −1.500 | 0.007255 | −1.550 | 0.029722 |
| let-7d-3p | – | – | – | – | −3.110 | 0.000057 | −3.010 | 0.003029 |
| let-7f-1-5p | 1.370 | 0.000069 | 1.540 | 0.001410 | – | – | – | – |
| let-7f-2-5p | – | – | – | – | −1.560 | 0.015669 | −1.970 | 0.017791 |
| miR-103a-1-3p | 1.690 | 0.000165 | 2.010 | 0.000033 | – | – | – | – |
| miR-103b-1-5p | 2.260 | 0.000814 | 2.480 | 0.007663 | – | – | – | – |
| miR-106a-5p | 2.140 | 0.000302 | 1.820 | 0.004509 | – | – | – | – |
| miR-106b-5p | 1.710 | 0.000151 | 1.790 | 0.000089 | – | – | – | – |
| miR-10a-5p | – | – | – | – | −1.850 | 0.001792 | −2.090 | 0.004312 |
| miR-1246-5p | 1.860 | 0.000235 | 1.250 | 0.020410 | – | – | – | – |
| miR-126-3p | – | – | – | – | −1.520 | 0.005143 | −1.690 | 0.010909 |
| miR-128-1-3p | – | – | – | – | −2.420 | 0.000065 | −2.150 | 0.007397 |
| miR-1307-3p | – | – | – | – | −1.880 | 0.000973 | −1.620 | 0.022368 |
| miR-132-5p | 3.540 | 0.000003 | 2.860 | 0.000472 | – | – | – | – |
| miR-139-5p | – | – | – | – | −2.490 | 0.000004 | −2.180 | 0.014812 |
| miR-140-3p | – | – | – | – | −1.540 | 0.002687 | −1.640 | 0.015714 |
| miR-142-3p | 1.700 | 0.000678 | 1.400 | 0.005392 | – | – | – | – |
| miR-143-3p | – | – | – | – | −2.680 | 0.000012 | −2.390 | 0.000177 |
| miR-144-3p | 2.250 | 0.000053 | 2.400 | 0.000078 | – | – | – | – |
| miR-144-5p | 2.880 | 0.000027 | 3.140 | 0.000008 | −2.000 | 0.002375 | −2.270 | 0.008368 |
| miR-146a-5p | – | – | – | – | −1.920 | 0.000464 | −1.540 | 0.038702 |
| miR-146b-5p | – | – | – | – | −2.380 | 0.000863 | −2.170 | 0.014685 |
| miR-148a-5p | 1.480 | 0.000307 | 1.340 | 0.007504 | – | – | – | – |
| miR-148b-3p | – | – | – | – | −1.510 | 0.015277 | −1.950 | 0.013167 |
| miR-151a-3p | – | – | – | – | −2.640 | 0.000149 | −2.370 | 0.009147 |
| miR-15a-5p | 2.050 | 0.001272 | 2.640 | 0.000201 | – | – | – | – |
| miR-15b-5p | 2.190 | 0.000060 | 2.390 | 0.001502 | – | – | – | – |
| miR-16-1-5p | 1.740 | 0.000021 | 1.860 | 0.000047 | – | – | – | – |
| miR-16-2-3p | – | – | – | – | −2.980 | 0.000011 | −2.790 | 0.000715 |
| miR-17-5p | 1.430 | 0.000155 | 1.910 | 0.000531 | – | – | – | – |
| miR-181a-1-5p | – | – | – | – | −1.770 | 0.001842 | −1.910 | 0.015319 |
| miR-182-5p | 1.760 | 0.000053 | 1.170 | 0.009230 | – | – | – | – |
| miR-183-5p | 2.060 | 0.000004 | 1.380 | 0.006866 | – | – | – | – |
| miR-184-3p | 2.570 | 0.000042 | 1.680 | 0.041781 | −2.760 | 0.000008 | −1.850 | 0.015228 |
| miR-185-3p | – | – | – | – | −2.090 | 0.000016 | −1.430 | 0.042859 |
| miR-18a-5p | 1.490 | 0.007164 | 2.000 | 0.001294 | – | – | – | – |
| miR-192-5p | – | – | – | – | −3.020 | 0.000007 | −2.920 | 0.004058 |
| miR-199a-1-3p | – | – | – | – | −2.850 | 0.000020 | −2.650 | 0.001332 |
| miR-19a-3p | 1.010 | 0.018209 | 1.150 | 0.014389 | – | – | – | – |
| miR-203a-3p | – | – | – | – | −1.140 | 0.017134 | −1.310 | 0.033100 |
| miR-20a-5p | 2.270 | 0.000012 | 2.680 | 0.000002 | – | – | – | – |
| miR-20b-5p | 2.120 | 0.000056 | 1.850 | 0.002363 | – | – | – | – |
| miR-21-5p | – | – | – | – | −1.320 | 0.049644 | −1.670 | 0.046573 |
| miR-222-3p | – | – | – | – | −2.150 | 0.000200 | −2.560 | 0.003303 |
| miR-223-3p | 1.230 | 0.002305 | 1.460 | 0.000817 | – | – | – | – |
| miR-223-5p | – | – | – | – | −2.080 | 0.001320 | −1.860 | 0.028278 |
| miR-2355-3p | 2.180 | 0.000086 | 1.650 | 0.005462 | – | – | – | – |
| miR-26a-1-5p | – | – | – | – | −2.350 | 0.000335 | −2.670 | 0.001216 |
| miR-27a-3p | – | – | – | – | −2.580 | 0.000007 | −2.100 | 0.025788 |
| miR-27b-3p | – | – | – | – | −2.480 | 0.000047 | −2.870 | 0.001527 |
| miR-30a-5p | – | – | – | – | −2.490 | 0.000488 | −2.440 | 0.003852 |
| miR-30d-5p | – | – | – | – | −2.660 | 0.000129 | −2.770 | 0.001729 |
| miR-30e-5p | – | – | – | – | −1.780 | 0.001842 | −1.700 | 0.012906 |
| miR-3158-1-3p | – | – | – | – | −1.350 | 0.021697 | −2.030 | 0.037187 |
| miR-32-5p | 2.180 | 0.000009 | 2.470 | 0.000528 | – | – | – | – |
| miR-340-5p | – | – | – | – | −3.470 | 0.000000 | −2.690 | 0.004273 |
| miR-342-5p | – | – | – | – | −1.980 | 0.000039 | −1.420 | 0.021622 |
| miR-3613-5p | 1.010 | 0.024744 | 1.370 | 0.007090 | – | – | – | – |
| miR-369-5p | – | – | – | – | −1.970 | 0.000000 | −1.850 | 0.044017 |
| miR-374b-5p | 1.070 | 0.014987 | 1.640 | 0.002041 | – | – | – | – |
| miR-379-5p | – | – | – | – | −1.720 | 0.001542 | −1.990 | 0.043900 |
| miR-411-5p | 2.480 | 0.000047 | 2.810 | 0.000216 | – | – | – | – |
| miR-423-3p | – | – | – | – | −2.250 | 0.000563 | −2.150 | 0.008162 |
| miR-423-5p | – | – | – | – | −1.780 | 0.001526 | −1.670 | 0.028619 |
| miR-4433b-3p | – | – | – | – | −1.690 | 0.001924 | −2.010 | 0.023562 |
| miR-4440-3p | 2.200 | 0.000207 | 1.450 | 0.044562 | – | – | – | – |
| miR-483-5p | – | – | – | – | −2.940 | 0.000004 | −2.290 | 0.030866 |
| miR-484-5p | 1.020 | 0.001705 | 1.160 | 0.000907 | – | – | – | – |
| miR-486-1-5p | – | – | – | – | −1.160 | 0.034682 | −1.520 | 0.042751 |
| miR-490-3p | 3.120 | 0.000009 | 2.590 | 0.001038 | – | – | – | – |
| miR-584-5p | – | – | – | – | −2.680 | 0.000027 | −2.640 | 0.001609 |
| miR-664a-5p | – | – | – | – | −2.210 | 0.000165 | −2.270 | 0.017894 |
| miR-7-5p | – | – | – | – | −1.390 | 0.004122 | −1.740 | 0.027532 |
| miR-7974-3p | – | – | – | – | −1.160 | 0.017294 | −1.190 | 0.030883 |
| miR-96-5p | 2.990 | 0.000014 | 3.440 | 0.000003 | – | – | – | – |
The affected miRNAs were determined based on a log 2-fold concentration change (log2 FC) of ≥ ±1 (a concentration change ≥ ± 2-fold) with p < 0.05 (unpaired t test). miRNAs that show concentration difference between chronic mTBI/CC and mTBI/DC are shown here.
CC, community controls; DC, deployed controls; EV, EV, extracellular vesicle; miRNA, microRNA;. mTBI, mild traumatic brain injury