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. 2020 May 27;37(12):1452–1462. doi: 10.1089/neu.2016.4644

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© Zachary S. Bailey, et al., 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 2. — Brain distribution of cerium oxide nanoparticles (CeONPs). As a measurement of CeONP content, brain cerium concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES) after a single injection of CeONP at the concentrations shown (Cerium Labs, Austin, TX). Even animals unexposed to CeONP have a basal level of cerium in the brain, as observed in saline-citrate treated controls. Note the dose-dependent increase in brain cerium with increasing concentration of CeONP. *Significant from saline, p < 0.01.