Table 3.
Baseline Feature Values by TBI Phenotype
| |
Phenotype A |
Phenotype B |
Phenotype C |
Phenotype A vs. phenotype C adjusted OR (95% CI) | |
Phenotype B vs. phenotype C adjusted OR (95% CI) | |
|---|---|---|---|---|---|---|---|
| Clinical feature | Median (IQR) | Median (IQR) | Median (IQR) | p value | p value | ||
| Platelet count (1000/μL) | 226 (74) | 216 (87) | 163 (76) | 1.02 (1.01–1.03) | < 0.0001 | 1.02 (1.01–1.03) | < 0.0001 |
| Hemoglobin (g/dL) | 12.4 (1.2) | 14.4 (1.4) | 10.1 (2.0) | 5.76 (4.61–7.19) | < 0.0001 | 6.48 (4.38–9.58) | < 0.0001 |
| Prothrombin time (sec) | 11 (3.0) | 13 (2.8) | 14.6 (3.1) | 0.48 (0.4–0.56) | < 0.0001 | 1.58 (1.26–1.97) | < 0.0001 |
| INR | 1.1 (0.1) | 1.1 (0.1) | 1.2 (0.2) | 0.72 (0.44–1.18) | 0.19 | 0.001 (0.0002–0.02) | < 0.0001 |
| Hematocrit (%) | 37 (3) | 42.5 (3) | 32 (4.5) | 1.73 (1.62–1.85) | < 0.0001 | 6.75 (5.94–7.67) | < 0.0001 |
| Glucose (mg/dL) | 127 (36) | 128 (36) | 145 (43) | 0.99 (0.98–0.99) | 0.0004 | 0.99 (0.98–1.0) | 0.13 |
(Columns 1–3) The median and interquartile range (IQR) of GLRM-selected baseline features in each phenotype, respectively. (Columns 4, 6) Multinomial logistical regression was used to calculate the adjusted odds ratio (OR) and 95% confidence intervals (CI) for the likelihood of phenotype membership based on the GLRM-selected predictor features, where phenotype C is the reference outcome variable. (Columns 5,7) Wald tests were used to calculate p values for each regression coefficient (p < 0.05 considered significant, bold font).
TBI, traumatic brain injury; INR, international normalized ratio; GLRM, generalized low-rank models.