Table 5.
Differences in the Occurrence of TBI-Specific Features among Baseline Phenotypes
| TBI specific feature | Phenotype A | Phenotype B | Phenotype C | p value |
|---|---|---|---|---|
| Intraventricular hemorrhage | 11% (48) | 11% (50) | 24% (84) | < 0.0001 |
| Lesion anatomical sites | ||||
| Intraparietal lesion in brainstem/diencephalon/corpus callosum | 4% (18) | 2% (11) | 6% (22) | 0.026 |
| Subdural lesion in left supratentorial region | 9% (39) | 16% (73) | 17% (58) | 0.002 |
| Abnormal mesencephalic cisterns | 30% (127) | 23% (102) | 47% (162) | < 0.0001 |
| Mechanism of injury | ||||
| Motor vehicle | 56% (236) | 44% (195) | 68% (235) | < 0.0001 |
| Fall | 31% (129) | 35% (158) | 26% (91) | |
| Other | 13% (55) | 21% (93) | 6% (21) | |
| Midline shift | ||||
| No shift | 79% (330) | 81% (362) | 73% (252) | < 0.0001 |
| 0–5 mm shift | 16% (67) | 16% (70) | 12% (43) | |
| 6–10 mm shift | 4% (18) | 2% (11) | 10% (36) | |
| > 10 mm shift | 1% (5) | 0.6% (3) | 5% (16) |
(Column 1) The subset of TBI-specific features that demonstrated significant differences in the frequency of patients in each phenotype presenting with these features. Radiology assessment findings on CT scan: presence of intraventricular hemorrhage, anatomical locations of lesions, and abnormal status of mesencephalic cisterns (abnormal status defined as blood-filled, compressed, or obliterated cisterns). Injury information: mechanisms of injury including motor vehicle accidents, falls, and other mechanisms, including assault and sports-related injuries. (Columns 2–5) The percentage and number of patients (expressed in parentheses) in each phenotype who presented with the selected TBI-related features. (Column 6) Statistically significant p values (p < 0.05) determined using Pearson's χ2 test.
TBI, traumatic brain injury; CT, computed tomography.