FIG. 12.

Blast-induced functional RGC damage post-repeated blast exposure is partially prevented by anakinra. There were no significant differences between groups at pre-blast baseline measurements (A). At four weeks post-injury, the pattern-evoked electroretinography (PERG) analysis revealed deficits in the blast-saline group, but not in the sham-anakinra or blast-anakinra groups (B), suggesting a partial rescue of RGC function. No other significant differences were found. All PERG recordings are of ipsilateral retinas and were measured in the neutral position. Significance was determined comparing means of all groups using Kruskal-Wallis test with the Dunn post-test (*p < 0.05, **p < 0.01). Data expressed as means ± SEM; n = 10–16.