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Biguanide Treatment Selectively Impairs the Growth of miR-17∼92-Expressing Lymphoma Cells In Vivo
(A and B) Kaplan-Meier curves for the viability of nude mice injected with 1 × 106Myc+/Ctrl (A) or Myc+/+17∼92 (B) lymphoma cells. Mice were provided with untreated water (Ctrl, n = 10), 0.9 mg/mL phenformin (Phen, n = 8), or 0.8 mg/mL IM156 (IM156, n = 10) ad libitum following intravenous tumor cell injection.
∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.
