Table 4.
LoxA substrates ordered by maximum turnover rate as a percentage of the fastest substrate (AA). Products made by each substrate were determined with approximate percentage of total product shown. N/D: not determined
| Substrate | % AA Rate (10 μM) | Product | Approximate % of total |
|---|---|---|---|
| AA | 100 | 15-HETE | 94 |
| 9-HETE | 6 | ||
| 11-HETE | <1 | ||
| ALA | 78(10) | 13-HOTrE | 91 |
| N/D | 9 | ||
| LA | 72(10) | 13-HODE | 93 |
| 9-HODE | 4 | ||
| DHA | 72(10) | 17-HDoHE | 93 |
| 4-HDoHE | 7 | ||
| 20-HDoHE | <1 | ||
| EPA | 61(10) | 15-HEPE | 78 |
| 18-HEPE | 14 | ||
| 11-HEPE | 8 | ||
| DGLA | 44(10) | 15-HETrE | 100 |
| GLA | 44(10) | 13-HOTrE(ϒ) | 78 |
| N/D | 20 | ||
| N/D | 2 | ||
| EDA | 33(10) | 15-HEDE | 70 |
| 11-HEDE | 30 |