Fig. 3.

FXR knockout reduced inflammation after ischemic injury. a Western blotting analysis of MPO in the striatum of ipsilateral hemisphere of sham mice (sham group), stroke mice treated with vehicle (vehicle group) and FXR knockout stroke mice (FXR KO group) at 3 days after stroke. Data are presented as mean ± SD, n = 4–5/group, *p < 0.05, **p < 0.01. b The mRNA level of TNF-α, IL-6, IL-1β, IL-17, and IL-18 in the striatum of sham group, vehicle group, and FXR KO group at 3 days after stroke. Data are presented as mean ± SD, n = 4–5/group, *p < 0.05, **p < 0.01, ***p < 0.001