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. 2020 May 25;17:164. doi: 10.1186/s12974-020-01838-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Bayk8644 treatment reversed the protective effects of FXR knockout after stroke in mice. a Experimental scheme. b Representative cresyl violet-stained brain sections at 3 days of sham mice (sham group), stroke mice treated with vehicle (vehicle group), FXR knockout stroke mice (FXR KO group), wild-type stroke mice treated with Bayk8644 (Bayk group), and FXR knockout stroke mice treated with Bayk8644 group (KO + Bayk group). n = 4–7/group. The brain infarction was circled by the dashed line, and bar graph showed the quantitative analysis of the infarct volume. Data are presented as mean ± SD. *p < 0.05, ***p < 0.001. c Brain atrophy at 14 days in sham group, vehicle group, FXR KO group, Bayk group, and KO + Bayk group were also detected by Cresyl violet; the dashed line represented brain atrophy. Bar graph showed the brain atrophy volume, Data are presented as mean ± SD. *p < 0.05, **p < 0.01. Neurobehavioral recovery was assessed by three separate neurobehavioral tests including modified neurological severity score (mNSS) (d), rotarod performance tests (e), and hanging wire tests (f, g), n = 15–20 per group. Data are presented as mean ± SD. *p < 0.05, **p < 0.01 (vehicle vs. Bayk8644 group). ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 (FXR KO group vs. FXR KO + Bayk8644). ^&p < 0.05, ^&&&p < 0.001 (Bayk8644 group vs. FXR KO + Bayk8644 group)