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. 2020 May 26;20:471. doi: 10.1186/s12885-020-06956-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Begg’s funnel plots and Egger’s publication bias plots for studies involved in the meta-analysis. Begg’s funnel plots for the studies included in meta-analysis regarding. OS (a) and TTP (b). Each hazard ratio (HR) was plotted on an HR scale against its standard error (SE). The horizontal lines indicate the pooled estimate of the overall HR, with the sloping lines reflecting the expected 95% confidence interval for a given SE. Egger’s publication bias plots for the studies included in meta-analysis regarding OS (c) and TTP (d). The 95% confidence intervals of the regression line’s y intercept include zero, P values were 0.59 and 0.89, respectively, indicating that there was no evidence of publication bias