Table 1.
Clinicopathological characteristics of SKCM patients
| Characteristics | FAHSU cohort (N = 46) | GEO cohort (N = 93) | TCGA cohort (N = 472) |
|---|---|---|---|
| N (%) | |||
| Age | |||
| ≤ 60 years | 21 (45.6) | 53 (56.9) | 258 (54.7) |
| > 60 years | 25 (54.4) | 40 (43.1) | 214 (45.3) |
| Gender | |||
| Male | 30 (65.2) | 55 (59.1) | 297 (61.9) |
| Female | 16 (34.8) | 38 (40.9) | 183 (38.1) |
| Clark level | |||
| I | 6 (13.0) | 13 (13.9) | 6 (1.8) |
| II | 25 (54.3) | 25 (26.8) | 18 (5.5) |
| III–IV | 12 (26.1) | 47 (50.7) | 246(75.5) |
| V | 3 (6.6) | 8 (8.6) | 56 (17.2) |
| Breslow depth(mm) | |||
| ≤ 0.75 | 5 (10.9) | 15 (16.1) | 36 (10.2) |
| 0.76–1.50 | 28 (60.9) | 30 (32.2) | 65 (18.4) |
| 1.51–4.00 | 11 (23.9) | 39 (41.9) | 106 (30.0) |
| > 4.00 | 2 (4.3) | 9 (9.8) | 146 (41.4) |
| pT stage | |||
| T1–T2 | 32 (69.6) | 57 (61.3) | 121 (32.7) |
| T3–T4 | 14 (30.4) | 36 (38.7) | 249 (67.3) |
| pN stage | |||
| N0 | 46 (100) | 93 (100) | 236 (65.0) |
| N1 | 0 (0) | 0 (0) | 75 (20.7) |
| N2 | 0 (0) | 0 (0) | 52 (14.3) |
| pM stage | |||
| M0 | 46 (100) | 93 (100) | 424 (94.4) |
| M1 | 0 (0) | 0 (0) | 25 (5.6) |
| Pathologic stage | |||
| I–II | 46 (100) | 93 (100) | 233 (53.9) |
| III–IV | 0 (0) | 0 (0) | 199 (46.1) |
| Persistent distant metastasis | |||
| No | 46 (100) | 93 (100) | 217 (46.1) |
| Yes | 0 (0) | 0 (0) | 254 (53.9) |
SKCM, Skin Cutaneous Melanoma
FAHSU, The First Affiliated Hospital of Soochow University
GEO, The Gene Expression Omnibus
TCGA, The Cancer Genome Atlas